Phase 4 Study of Effects of ARB Compared With Diuretics in Hypertension Patients With High Cardiovascular Risks (CHIEF)

NCT01011660 Phase 4 UNKNOWN

The aim of the study is to investigate the optimized treatment strategy of hypertension, so as to make more patients to reach the blood pressure goals and to reduce cardio-cerebrovascular events. Objective and Methods: Patients are eligible for inclusion in the study if they are essential hypertension, 50-79 years of age with at least one cardiovascular risk factor and sign the informed consent forms. This project is a multi-centre, prospective randomized,，openlabel blind-endpoint evaluation controlled (PROBE) trial. 12000 patients will be randomly assigned to either of low-dose Amlodipine+Telmisartan group or Amlodipine+ diuretics group. Among those patients with serum cholesterol between 4.0-6.1mmol/L, they will be also randomized into small dose of statin-based regimen or standard management regimen; Patients will also randomly assigned to intensive lifestyle intervention group or standard intervention group according to the community area where the patients in.

Details

Lead sponsor	Chinese Academy of Medical Sciences, Fuwai Hospital
Phase	Phase 4
Status	UNKNOWN
Enrolment	13542
Start date	2007-10
Completion	2012-12

Conditions

• Essential Hypertension

Interventions

• Amlodipine, Telmisartan, Amiloride Compound , Simvastatin

Primary outcomes

• The primary study outcomes are composite of non-fatal stroke, non-fatal myocardial infarction and cardiovascular death. — 3-4 years

Countries

China