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NCT00995657
Dose Response of FENO to Inhaled Steroids in Mild-to-moderate Asthma
Phase 4 trial testing Fluticasone Propionate in Asthma in 21 participants. Completed in 1 December 2011.
1 December 2011
Quick facts
| Lead sponsor | University of Dundee |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 21 |
| Start date | 1 October 2009 |
| Primary completion | 1 December 2011 |
| Estimated completion | 1 December 2011 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Fluticasone Propionate (FLUTICASONE PROPIONATE) — full drug profile →
- Fluticasone Propionate (FLUTICASONE PROPIONATE) — full drug profile →
Conditions studied
- Asthma — all drugs for Asthma →
Sponsor
University of Dundee
Who can join
Adults 18 to 65, any sex, with Asthma. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Change in FENO
Time frame: 2 weeks
Sponsor's own description
Asthma is a chronic disease, which means that it cannot be cured, but the investigators can use inhalers and tablets to control the symptoms. In asthma, the airways become inflamed and irritated which can cause coughing and make the airways tighten. This 'inflammation' is the root of the problem in asthma. Doctors have different ways to measure the inflammation in the airways. One way is to measure a gas called nitric oxide (NO) on the breath. This is made by the lungs when asthmatic inflammation is present. The investigators have been using NO as a test in research labs for many years, but there are still unanswered questions about how it changes between morning and night and how quickly medicines work on it. In most asthmatics, even small doses of inhaled steroids (preventers) can reduce the NO levels to normal, but in some people this does not seem to happen. The investigators now have portable NO machines that are designed for patients to use in the home. The investigators want to follow NO readings in patients with high levels to measure how they respond to different doses of steroid inhalers. The investigators hope this will help the investigators better understand asthma inflammation and treatments.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Inhaled corticosteroid dose response using domiciliary exhaled nitric oxide in persistent asthma: the FENOtype trial.
Anderson WJ, Short PM, Williamson PA, Lipworth BJ. · · 2012 · cited 46× · PMID 23364390 · DOI 10.1378/chest.12-1310 -
Inhaled corticosteroid dose response in asthma: Should we measure inflammation?
Anderson WJ, Short PM, Jabbal S, Lipworth BJ. · · 2017 · cited 5× · PMID 28065396 · DOI 10.1016/j.anai.2016.11.018
Verify or expand the search:
- PubMed search for NCT00995657
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Dundee trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00995657 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Dundee
- Last refreshed: 10 April 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00995657.
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