Randomized,Double-blind Trial Comparing the Effects of a 3-month Clopidogrel Regimen,Combined With ASA During the First 21days,Versus ASA Alone for the Acute Treatment of TIA or Minor Stroke (CHANCE)

NCT00979589 Phase 3 COMPLETED

The purpose of this study is to assess the effects of a 3-month regimen of clopidogrel initiated with a loading dose (LD) of 300 mg followed by 75 mg/day during the first 21days versus a 3-month regimen of ASA 75 mg/day alone on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in high-risk patients with TIA or minor stroke.

Details

Lead sponsor	Beijing Tiantan Hospital
Phase	Phase 3
Status	COMPLETED
Enrolment	5100
Start date	2009-12
Completion	2012-06

Conditions

• Stroke
• Transient Ischemic Attack

Interventions

• Clopidogrel
• Placebo of clopidogrel and Asprin

Primary outcomes

• Percentage of patients with the 3-month new vascular events, defined as any event of the following: Any stroke (ischemic or hemorrhage) — 3 months

Countries

China