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The Effect of FOsamprenavir/Ritonavir on the Pharmacokinetics of a Single-dose of the Antipsychotic Agent olanZApine (FORZA)
The effect of fosamprenavir/ritonavir (steady state) on the pharmacokinetics of a single dose of olanzapine will be studied. In this study, the investigators expect an inducible effect of fosamprenavir/ritonavir on the CYP1A2 and UGT metabolism of olanzapine.
Details
| Lead sponsor | Radboud University Medical Center |
|---|---|
| Phase | Phase 1 |
| Status | COMPLETED |
| Enrolment | 24 |
| Start date | 2009-11 |
| Completion | 2010-08 |
Conditions
- HIV Infections
Interventions
- fosamprenavir/ritonavir
- olanzapine
- olanzapine
Primary outcomes
- olanzapine concentrations — pharmacokinetic curve after a single dose of olanzapine alone or added to steady state fosamprenavir/ritonavir
Countries
Netherlands