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Pseudo-randomised, Double-blinded Placebo-controlled Trial of Chloroquine or Sulphadoxine-pyrimethamine Alone or in Combination With Primaquine or Artesunate for the Treatment of Uncomplicated Falciparum Malaria in Pakistan
This study is an evaluation of the benefit of adding artesunate to existing first and second line antimalarial therapies in Pakistan. A placebo controlled trial was carried out to assess two potential benefits of Artesunate Combination Therapy (ACT): efficacy and potential for transmission reduction.
Details
| Lead sponsor | London School of Hygiene and Tropical Medicine |
|---|---|
| Phase | Phase 2 |
| Status | COMPLETED |
| Enrolment | 588 |
| Start date | 2001-07 |
| Completion | 2006-08 |
Conditions
- Uncomplicated Falciparum Malaria
Interventions
- artesunate (AS)
- sulphadoxine-pyrimethamine (SP)
- Chloroquine (CQ)
- primaquine (PQ)
Primary outcomes
- Parasitological outcome after 28 days follow-up — 28 days
Countries
Pakistan