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NCT00947713
Comparison of Micro-dose Human Chorionic Gonadotropin (hCG) With HMG in PCOs Patients With Previous Clomiphene Citrate (CC)-Resistant Anovulation
Phase 1/Phase 2 trial testing low dose human chorionic gonadotropin in Endocrine System Diseases in 10 participants. Completed in 1 December 2010.
1 August 2010
Quick facts
| Lead sponsor | Royan Institute |
|---|---|
| Phase | Phase 1/Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 10 |
| Start date | 1 August 2009 |
| Primary completion | 1 August 2010 |
| Estimated completion | 1 December 2010 |
| Sites | 1 location across Iran |
Drugs / interventions tested
- low dose human chorionic gonadotropin — full drug profile →
- Clomiphen citrate plus HMG — full drug profile →
Conditions studied
- Endocrine System Diseases — all drugs for Endocrine System Diseases →
- Gonadal Disorders — all drugs for Gonadal Disorders →
Sponsor
Royan Institute
Who can join
Adults 18 to 30, female only, with Endocrine System Diseases or Gonadal Disorders. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Multiple pregnancy rates, OHSS rate
Time frame: Within 20 months after recruiting
Sponsor's own description
The purpose of this study is to compare the effectiveness of low dose human chorionic gonadotropin (HCG) in combination with clomiphen citrate to induce ovulation and its endocrine response in patients who had previously failed to ovulate on clomiphen citrate alone. The investigators will also compare the effectiveness and endocrine response of this approach with the regimen of adding HMG to clomiphen citrate.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Gonadotropins for ovulation induction in women with polycystic ovary syndrome.
Weiss NS, Kostova EB, Mol BWJ, van Wely M. · · 2025 · cited 2× · PMID 40193219 · DOI 10.1002/14651858.cd010290.pub4
Verify or expand the search:
- PubMed search for NCT00947713
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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- NCT05778071 — Evaluation of the Safety and Efficacy of Eneboparatide (AZP-3601) in Patients With Chronic Hypoparathyroidism · Phase 3 · active not recruiting
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Other Royan Institute trials
Trials by the same sponsor.
- NCT06199024 — Cinnamon and COH in PCOS Women Underdoing IVF/ICSI Cycles · NA · unknown
- NCT06202547 — Intra-ovarian Injection of MSC-EVs in Idiopathic Premature Ovarian Failure · Phase 1, PHASE2 · unknown
- NCT05460858 — NAC Effect on Infertile Women With Endometrioma · Phase 3 · unknown
- NCT04855383 — Intramuscular Injection of Human Chorionic Gonadotropin in Frozen Embryo Transfer Cycles · NA · completed
- NCT04600986 — Repeated Doses of GnRH Agonist as Oocyte Triggering in Antagonist Protocol for Patients With Polycystic Ovary Syndrome · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00947713 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Royan Institute
- Last refreshed: 14 July 2011
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00947713.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing