NCT00938379

Clinical Evaluation of Insect Repellent and Insecticide Treated Nets Against Malaria, JE & Dengue in Rural Communities in Lao PDR

Status unknown Phase 3 Last updated 13 July 2009

What this trial tests

Phase 3 trial testing 20% deet insect repellent in Malaria in 5,000 participants. Status unknown.

Timeline

1 July 2009

Primary endpoint
1 December 2010

1 June 2011

Quick facts

Lead sponsor	London School of Hygiene and Tropical Medicine
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	5,000
Start date	1 July 2009
Primary completion	1 December 2010
Estimated completion	1 June 2011
Sites	1 location across Laos

Drugs / interventions tested

• 20% deet insect repellent — full drug profile →
• placebo control

Conditions studied

• Malaria — all drugs for Malaria →
• Dengue — all drugs for Dengue →
• Japanese Encephalitis — all drugs for Japanese Encephalitis →

Sponsor

London School of Hygiene and Tropical Medicine

Who can join

Adults 5 to 70, any sex, with Malaria or Dengue. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• reduction in malaria incidence
  Time frame: monthly over 7 months

Sponsor's own description

Rural communities involved in agriculture are often at highest risk of insect-borne diseases in Southeast (SE) Asia.

Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases for those people working outdoors in high risk areas.

This trial is evaluating the use of insect repellent (20% diethyltoluamide) to reduce incidence of malaria, Japanese Encephalitis and Dengue. The investigators will recruit up to 1000 households from 100 villages in rural Laos. In each house the investigators shall recruit up to 5 individuals. Half of households will be randomised to repellent, half to a placebo. All individuals will be provided with insecticide treated bed nets for use at night. All household occupants will be followed for 7 months to record malaria cases by Rapid Diagnostic Test every month. Blood spots will be collected at start and end of study to measure Japanese Encephalitis and Dengue. All positive cases will be promptly treated. Outcome will be reduction in number of malaria cases (primary outcome) and Dengue/Japanese Encephalitis (secondary outcomes).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Mosquito repellents for malaria prevention.
   Maia MF, Kliner M, Richardson M, Lengeler C, et al · · 2018 · cited 67× · PMID 29405263 · DOI 10.1002/14651858.cd011595.pub2
2. Can topical insect repellents reduce malaria? A cluster-randomised controlled trial of the insect repellent N,N-diethyl-m-toluamide (DEET) in Lao PDR.
   Chen-Hussey V, Carneiro I, Keomanila H, Gray R, et al · · 2013 · cited 34× · PMID 23967083 · DOI 10.1371/journal.pone.0070664