Interplay Between Organic Anion Transporting Polypeptide (OATP) Transporters Transporters and CYP2C9 in Glyburide Pharmacokinetics (PK)

NCT00935363 Phase 1 WITHDRAWN

The purpose of this study is to investigate if the drugs rifampin and fluconazole when given together increase the concentrations in the body of the oral diabetes medication glyburide.

Details

Lead sponsor	University of California, San Francisco
Phase	Phase 1
Status	WITHDRAWN
Start date	2010-02
Completion	2010-04

Conditions

• Healthy

Interventions

• glyburide
• glyburide + fluconazole
• glyburide + rifampin
• glyburide + fluconazole + rifampin

Primary outcomes

• Drug Plasma Levels — 24 hours