First Pilot Study Evaluating the Life Span of Autologous Cultured Red Blood Cells (cRBC) Generated From Peripheral Stem Cells in Three Healthy Volunteers - Feasibility Study (GRc2008)

NCT00929266 NA COMPLETED

To study the in vivo life span in healthy volunteers of red blood cells generated in vitro from autologous peripheral stem cells. The study will be carried out in 4 phases : * production in vitro of the equivalent of 1 ml of blood, i.e. 5x10e9 enucleated RBC from mononuclear cells isolated from an HSC graft obtained from a healthy volunteers donor. * labeling of these cRBC with 51 Cr * reinjection of the autologous cRBC * follow up of the receivers for a maximum 33 days to measure the half-life span of the injected cells.

Details

Lead sponsor	Etablissement Français du Sang
Phase	NA
Status	COMPLETED
Enrolment	1
Start date	2010-05
Completion	2012-02

Conditions

• Healthy Volunteers

Interventions

• intravenous injection of labeled cRBC

Primary outcomes

• Study of the life span in vivo of cultured Red Blood Cells. — At T+24h, T+48h and day 30

Countries

France