A Randomised Placebo-controlled Trail of Mechanical and Cold Hyperalgesia in Subjects With Painful Knee Osteoarthritis, Compared With Matched Controls, & Whether This Hyperalgesia Can be Modified by a 2-week Course of Etoricoxib 60mg.

NCT00927004 Phase 4 COMPLETED

This study aims to better understand the way in which painful osteoarthritis affects different people and whether an anti-inflammatory medication such as Arcoxia (etoricoxib) can help to modify this pain. The study will use questionnaires and tests of pain sensitivity to identify arthritis sufferers with more widespread, nerve-type pain and then to investigate whether a daily dose of Arcoxia is more effective than a placebo pill in reducing these symptoms and improving functional movements. The study will also be comparing the same test results of a small group of subjects without knee pain.

Details

Lead sponsor	Curtin University
Phase	Phase 4
Status	COMPLETED
Enrolment	80
Start date	2010-08
Completion	2011-12

Conditions

• Osteoarthritis
• Pain

Interventions

• Etoricoxib (Arcoxia)
• Sugar pill

Primary outcomes

• Pressure Pain Threshold — 15 days, 3 days
• Western Ontario and McMaster University Osteoarthritis Index (knee) - pain subscale — 15 days, 3 days

Countries

Australia