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Advancing Niacin by Inhibiting FLUSHing: (ANTI-FLUSH)
Niacin, or vitamin B3, is known to improve cholesterol disorders and is the most effective drug to raise HDL, or the "good cholesterol". The use of niacin has been limited because of a peculiar adverse effect referred to as "flushing', which consists of redness, warmth, tingling and burning. A recent animal study suggests that flavonoids may prevent flushing due to niacin better than drugs like aspirin. The ANTI-FLUSH study is being done to assess whether a presently available dietary supplement known as quercetin, which is a flavonoid, can reduce the flushing that occurs with niacin. We will also assess whether using quercetin to prevent flushing from niacin, can improve how niacin lowers cholesterol.
Details
| Lead sponsor | University of Pennsylvania |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 17 |
| Start date | 2009-02 |
| Completion | 2009-12 |
Conditions
- Flushing
Interventions
- Quercetin
- Placebo
Primary outcomes
- Whether Quercetin Dose-dependently Reduces Laser Doppler Flux Index Primary Peak Following Immediate-release Niacin — 8 hour period
Laser Doppler flowmetry at the malar eminence measures blood flow quantitatively as red blood cell flux. Flux index is the fold-change in flux over baseline. Flux index primary peak is the maximum flux index between 0-4 hours after niacin.
Countries
United States