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NCT00904046: IUAN
Pathophysiology of Uric Acid Nephrolithiasis
NA trial testing Pioglitazone in Uric Acid Kidney Stone Disease in 172 participants. Completed in 16 November 2017.
16 November 2017
Quick facts
| Lead sponsor | University of Texas Southwestern Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 172 |
| Start date | 15 January 2010 |
| Primary completion | 16 November 2017 |
| Estimated completion | 16 November 2017 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Pioglitazone (pioglitazone) — full drug profile →
- Placebo
Conditions studied
- Uric Acid Kidney Stone Disease — all drugs for Uric Acid Kidney Stone Disease →
Sponsor
University of Texas Southwestern Medical Center
Who can join
Adults 21 to 99, any sex, with Uric Acid Kidney Stone Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study has two aims: Aim 1: To determine the presence of accumulation of fat within cells and the functional consequences of this in the kidney by correlating kidney fat content with urine test results. Aim 2: The investigators will evaluate the effect of thiazolidinedione (pioglitazone) on excess fatty acid accumulation in kidney tissue and its correlation with uric acid stone formation in subjects with uric acid stones. Pioglitazone is already U.S. Food \& Drug Administration (FDA)-approved for the treatment of type 2 diabetes, but is not approved by the FDA for treating or preventing or diagnosing stone risk.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT00904046
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Pioglitazone
Trials testing the same drug.
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- NCT06246799 — Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes · Phase 3 · recruiting
- NCT05753657 — A Pilot Study of Monitoring Insulin Levels and Treating Hyperinsulinemia and Hyperglycemia With Pioglitazone in Patients · EARLY_PHASE1 · recruiting
- NCT05305287 — Quantifying Hepatic Mitochondrial Fluxes in Humans · Phase 4 · recruiting
Other University of Texas Southwestern Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00904046 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Texas Southwestern Medical Center
- Last refreshed: 11 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00904046.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing