Lamotrigine as an Antidepressant Augmentation Agent in Treatment Refractory Unipolar Depression

NCT00901407 NA COMPLETED

This study is intended to evaluate the efficacy and safety of lamotrigine as an antidepressant augmentation agent in a sample of individuals with major depression and a history of both prior non-response and prospective failure to respond to at least one adequate trial of an antidepressant (for a total of two failed trials).

Details

Lead sponsor	Louisiana State University Health Sciences Center in New Orleans
Phase	NA
Status	COMPLETED
Enrolment	138
Start date	2003-12
Completion	2007-04

Conditions

• Unipolar Depression

Interventions

• lamotrigine
• placebo
• paroxetine

Primary outcomes

• MADRS score — weeks 0 (randomization); 8, 9, 10, 12, 14, 16, 18, and 20

Countries

United States