Last reviewed · How we verify
NCT00900419
Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
trial testing immunohistochemistry staining method in Esophageal Cancer in 700 participants. Currently enrolling.
30 September 2027
Quick facts
| Lead sponsor | University of Colorado, Denver |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 700 |
| Start date | 3 May 2001 |
| Primary completion | 30 September 2027 |
| Estimated completion | 30 September 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- immunohistochemistry staining method
- laboratory biomarker analysis — full drug profile →
- sputum cytology — full drug profile →
- biopsy — full drug profile →
Conditions studied
- Esophageal Cancer — all drugs for Esophageal Cancer →
- Head and Neck Cancer — all drugs for Head and Neck Cancer →
- Lung Cancer — all drugs for Lung Cancer →
- Precancerous Condition — all drugs for Precancerous Condition →
Sponsor
University of Colorado, Denver
Who can join
Adults 21 to 90, any sex, with Esophageal Cancer or Head and Neck Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This laboratory study is looking at biomarkers in patients with respiratory tract dysplasia or lung cancer, head and neck cancer, or aerodigestive tract cancer.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Lung adenocarcinoma promotion by air pollutants.
Hill W, Lim EL, Weeden CE, Lee C, et al · · 2023 · cited 544× · PMID 37020004 · DOI 10.1038/s41586-023-05874-3 -
Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease.
Ghosh M, Miller YE, Nakachi I, Kwon JB, et al · · 2018 · cited 98× · PMID 29211494 · DOI 10.1164/rccm.201704-0667oc -
Non-Small-Cell Lung Cancer Promotion by Air Pollutants
Swanton C, Hill W, Lim E, Lee C, et al · · 2022 · DOI 10.21203/rs.3.rs-1770054/v1
Verify or expand the search:
- PubMed search for NCT00900419
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Colorado, Denver trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00900419 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Colorado, Denver
- Last refreshed: 22 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00900419.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing