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NCT00880607
The Use of Intraoperative Intrathecal Morphine Versus Epidural Extended Release Morphine for Postoperative Pain Control in Pediatric Patients Undergoing Posterior Spinal Fusion
Phase 4 trial testing Intrathecal morphine in Pain Management in 84 participants. Completed in 1 September 2012.
1 April 2011
Quick facts
| Lead sponsor | University of Colorado, Denver |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 84 |
| Start date | 1 December 2008 |
| Primary completion | 1 April 2011 |
| Estimated completion | 1 September 2012 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Intrathecal morphine — full drug profile →
- Extended Release Epidural Morphine
Conditions studied
- Pain Management — all drugs for Pain Management →
- Spinal Fusion — all drugs for Spinal Fusion →
- Scoliosis — all drugs for Scoliosis →
Sponsor
University of Colorado, Denver
Who can join
Adults 8 to 17, any sex, with Pain Management or Spinal Fusion. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
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Total IV Morphine Consumption up to 48 Hours Post Surgery
Time frame: Four hour intervals for up to 48 hours
Total IV morphine consumption during the first 0- 48 hours after surgery.Postoperative pain was treated with morphine PCA, ketorolac, oral oxycodone, and acetaminophen.
Sponsor's own description
This study plans to learn more about preventing pain in children who are having posterior spinal fusion surgery using two different kinds of morphine (a pain medicine). Also, this study plans to learn about individual differences in the how the different kinds of morphine work in children. Subjects are being asked to be in this research study because they are having spinal fusion surgery, will have pain some of the time and will be getting morphine during and after surgery to help control their pain.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Intrathecal Morphine Versus Extended-Release Epidural Morphine for Postoperative Pain Control in Pediatric Patients Undergoing Posterior Spinal Fusion.
Cohen M, Zuk J, McKay N, Erickson M, et al · · 2017 · cited 16× · PMID 28448398 · DOI 10.1213/ane.0000000000002061
Verify or expand the search:
- PubMed search for NCT00880607
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Intrathecal morphine
Trials testing the same drug.
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- NCT05742958 — The Quality of Recovery After Intrathecal Morphine or Adductor Canal Block in Anterior Cruciate Ligament Reconstruction · Phase 4 · unknown
Other recruiting trials for Pain Management
Currently open trials in the same condition.
- NCT07369024 — Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults · Phase 2 · recruiting
- NCT07410000 — Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty · NA · recruiting
- NCT07467356 — Anterior Iliopsoas Space Block Versus PENG Block on Ease of Positioning for Spinal Anathesia in Patients Undergoing Hip · Phase 3 · recruiting
- NCT07454993 — The Effect of Music During Colonoscopy · NA · recruiting
- NCT07442539 — The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Hemorrhoid Surgery · NA · recruiting
Other University of Colorado, Denver trials
Trials by the same sponsor.
- NCT07292285 — The Surveillance Nonoperative Watch & Wait (SNOWW) Rectal Cancer Trial. · not yet recruiting
- NCT07021937 — Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity · Phase 3 · not yet recruiting
- NCT07453732 — Banana Leaves as a Wound Dressing for Partial Thickness Second Degree Burns in Adult Patients. · NA · not yet recruiting
- NCT07038278 — 5-AminoLevulinic Acid Aided Resection Margins in Sarcoma · EARLY_PHASE1 · not yet recruiting
- NCT07279558 — Cannabidiol and Alcohol Use Disorder Phenotypes · Phase 2 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00880607 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Colorado, Denver
- Last refreshed: 21 April 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00880607.
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