A Randomised Trial to Assess Catheter Ablation Versus Rate-Control in the Management of Persistent Atrial Fibrillation in Chronic Heart Failure (ARC-HF)

NCT00878384 NA COMPLETED

It is still uncertain what the best treatment is for patients who have both atrial fibrillation (AF) and heart failure. The aim of the study is to help identify the optimal treatment for patients with these two significant medical conditions. This will be performed by comparing two alternative strategies for AF management: catheter ablation (to restore normal rhythm) and medical therapy (to control heart rate, but not aiming ro restore normal rhythm). After random assignment, the effect of each strategy will be assessed by looking for changes in exercise capacity, symptoms, heart pump function, and quality of life during 12 months of follow-up.

Details

Lead sponsor	Royal Brompton & Harefield NHS Foundation Trust
Phase	NA
Status	COMPLETED
Enrolment	52
Start date	2009-04
Completion	2012-07

Conditions

• Atrial Fibrillation
• Heart Failure

Interventions

• Medication to control ventricular rate in AF
• Catheter Ablation for Persistent Atrial Fibrillation

Primary outcomes

• Peak oxygen consumption at cardiopulmonary exercise test — 12 months

Countries

United Kingdom