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Anti-GD2 3F8 Antibody and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma
Funding Source - FDA OOPD FDR004128 The goal of this study is to see if it is safe and feasible to give chemotherapy, natural killer (NK) cells, and an antibody called 3F8. The NK cells must come from a family member who shares half of the HLA proteins which are immune proteins important in transplant. NK cells are a type of white blood cell. They can recognize and kill abnormal cells in the body and can work together with antibodies to kill target cells. The antibody 3F8 specifically recognizes a protein present on the target cancer cell.
Details
| Lead sponsor | Memorial Sloan Kettering Cancer Center |
|---|---|
| Phase | PHASE1 |
| Status | COMPLETED |
| Enrolment | 71 |
| Start date | Thu Apr 02 2009 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Jan 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Neuroblastoma
- Bone Marrow, Sympathetic Nervous System
Interventions
- cyclophosphamide, vincristine, topotecan ,allogeneic NK cells & 3F8
Countries
United States