High Cut-off Continuous Venovenous Hemodialysis (CVVHD) to Improve Hemodynamic Stability and Organ Function Scores in Patients Treated for Acute Renal Failure After Systemic Inflammatory Response Syndrome (SIRS)/Septic Shock (HICOSS)

NCT00875888 NA TERMINATED

This study will assess the influence of the High Cut-Off (HCO) CVVHD treatment on the disease progression in septic patients. The primary aim of the study is to evaluate whether HCO CVVHD leads to a significant improvement of the hemodynamic status (mean arterial pressure, vasopressor requirements) in septic patients in comparison to CVVHD treatment with conventional high-flux filters. For the HCO-group the investigators expect a 50% lower dosage of vasopressors needed to maintain an adequate organ perfusion.

Details

Lead sponsor	Vantive Health LLC
Phase	NA
Status	TERMINATED
Enrolment	80
Start date	2004-02
Completion	2009-06

Conditions

• Systemic Inflammatory Response Syndrome
• Kidney Failure, Acute

Interventions

• continuous venovenous hemodialysis

Primary outcomes

• Dosage of vasopressors — day 1 to day 5
• Mean arterial pressure — day before inclusion and day 1 to day 5
• Heart rate — day before inclusion and day 1 to day 5
• Central venous pressure — day before inclusion and day 1 to day 5

Countries

Austria, Germany