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NCT00871156
Tafenoquine/Chloroquine DDI Study
Completed
Phase 1
Last updated 19 June 2017
What this trial tests
Phase 1 trial testing Chloroquine, Tafenoquine in Malaria in 68 participants. Completed in 26 August 2009.
Timeline
24 March 2009
Primary endpoint
26 August 2009
26 August 2009
26 August 2009
Quick facts
| Lead sponsor | GlaxoSmithKline |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | other |
| Enrollment | 68 |
| Start date | 24 March 2009 |
| Primary completion | 26 August 2009 |
| Estimated completion | 26 August 2009 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Chloroquine, Tafenoquine — full drug profile →
- Placebo
Conditions studied
- Malaria — all drugs for Malaria →
Sponsor
GlaxoSmithKline — full company profile →
Who can join
Adults 18 to 55, any sex, with Malaria. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
DDI study of Tafenoquine and Chloroquine
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects.
Miller AK, Harrell E, Ye L, Baptiste-Brown S, et al · · 2013 · cited 36× · PMID 23701202 · DOI 10.1111/bcp.12160 -
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19.
Delaunois A, Abernathy M, Anderson WD, Beattie KA, et al · · 2021 · cited 23× · PMID 33620150 · DOI 10.1111/cts.13011 -
Tafenoquine: A 2018 Novel FDA-Approved Prodrug for the Radical Cure of <i>Plasmodium vivax</i> Malaria and Prophylaxis of Malaria.
Mayence A, Vanden Eynde JJ. · · 2019 · cited 13× · PMID 31366060 · DOI 10.3390/ph12030115
Verify or expand the search:
- PubMed search for NCT00871156
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Malaria
Currently open trials in the same condition.
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- NCT07036159 — A Study to Assess the Safety and Immunogenicity of a Vaccine Against Malaria in Healthy Children Aged 5-60 Months · Phase 2 · recruiting
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- NCT06854042 — A Study of Oral E1018 in Healthy Adult Participants · Phase 1 · recruiting
- NCT06607003 — Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Cha · Phase 1 · recruiting
Other GlaxoSmithKline trials
Trials by the same sponsor.
- NCT07569081 — A Study Evaluating the Efficacy and Safety of Momelotinib in Participants With Vacuoles, E1-enzyme, X-linked, Autoinflam · Phase 2, PHASE3 · not yet recruiting
- NCT07406347 — A Trial to Evaluate the Safety and Reactogenicity of an Investigational Pneumococcal Vaccine in Infants Receiving 3-dose · Phase 1 · not yet recruiting
- NCT07286266 — A Study to Investigate GSK5733584 Compared With Chemotherapy in Participants With Platinum-resistant Ovarian Cancer (BEH · Phase 3 · not yet recruiting
- NCT07286331 — A Study to Investigate GSK5733584 Compared With Chemotherapy in Participants With Recurrent Endometrial Cancer (BEHOLD-E · Phase 3 · not yet recruiting
- NCT07406334 — A Trial to Evaluate the Safety and Reactogenicity of an Investigational Pneumococcal Vaccine in Toddlers 12 to 15 Months · Phase 1 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT00871156 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by GlaxoSmithKline
- Last refreshed: 19 June 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00871156.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing