Prospective, Randomized, Double-blinded, Placebo-controlled Study of N-acetylcysteine Plus Deferoxamine for Patients With Hypotension as Prophylaxis for Acute Renal Failure

NCT00870883 Phase 2 COMPLETED

Oxidative stress is associated with kidney damage in several different situations, including hypotension. In animal models it has been shown that the combination of n-acetylcysteine plus deferoxamine is superior to its isolate use in the treatment of several diseases. Thus the investigators aimed to determine if the administration of n-acetylcysteine plus deferoxamine could prevent renal failure in critical ill patients who develops hypotension.

Details

Lead sponsor	Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Phase	Phase 2
Status	COMPLETED
Enrolment	81
Start date	2009-03
Completion	2015-05

Conditions

• Hypotension
• Acute Renal Failure

Interventions

• N-acetylcysteine and deferoxamine

Primary outcomes

• Development of acute renal failure — 28 days

Countries

Brazil