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Randomized Control Trial of Early vs Delayed ART in the Treatment of Cryptococcal Meningitis.
Cryptococcal Meningitis continues to be one of the most devastating AIDS defining illness in sub-Saharan Africa. Despite the availability of azoles such as fluconazole for treatment, mortality remains high with some studies showing 100% mortality. The investigators designed a study to determine if timing of the initiation of antiretroviral therapy (ART) in patients with cryptococcal meningitis and HIV would improve survival. The investigators hypothesis was that early initiation of ART result in improved mortality for patients with HIV and cryptococcal meningitis.
Details
| Lead sponsor | University of Zimbabwe |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 54 |
| Start date | 2006-10 |
| Completion | 2009-10 |
Conditions
- Cryptococcal Meningitis
- HIV Infections
Interventions
- Fluconazole
- Fixed dose - Stavudine, lamivudine and Nevirapine
- Fixed dose - Stavudine, Lamivudine, Nevirapine
Primary outcomes
- Mortality — 2 years
Countries
Zimbabwe