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Evaluation of the Safety and Efficacy of Mefloquine as Intermittent Preventive Treatment of Malaria in Pregnancy (MiPPAD)
The study aims at comparing the safety, tolerability and efficacy of Mefloquine (MQ) to Sulfadoxine-Pyrimethamine (SP) as Interment Preventive Treatment in pregnancy (IPTp) for the prevention of malaria effects on the mother and her infant.
Details
| Lead sponsor | Hospital Clinic of Barcelona |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 5820 |
| Start date | 2009-09 |
| Completion | 2013-12 |
Conditions
- Pregnancy
- Malaria
- HIV Infections
Interventions
- Sulphadoxine-pyrimethamine
- Mefloquine (full dose)
- Mefloquine (split dose)
- placebo
- mefloquine
Primary outcomes
- Trial 1 (IPTp MQ vs IPTp SP): Low birth weight. — day 0, birth
- Trial 2 (CTX+IPTp MQ vs. CTX+IPTp placebo): Peripheral parasitaemia. — day 0, delivery
Countries
Benin, Gabon, Kenya, Mozambique, Tanzania