Efficacy and Safety of Prednisolone and Chloroquine Add on Therapy in Osteoarthritis of the Knee Treated With Fixed Dose Combination of Glucosamine and Chondroitin Sulfate.

NCT00805519 Phase 4 COMPLETED

This study was conducted to evaluate the efficacy and safety of prednisolone and chloroquine add on therapies to combined glucosamine, chondroitin sulfate in osteoarthritis of the knee which will be done in contrast to combined glucosamine sulfate and chondroitin.

Details

Lead sponsor	Ardabil University of Medical Sciences
Phase	Phase 4
Status	COMPLETED
Enrolment	230
Start date	2009-02
Completion	2010-04

Conditions

• Osteoarthritis of the Knee

Interventions

• Glucosamine and chondroitin sulfate
• glucosamine and chondroitin sulfate plus Prednisolone
• Glucosamine and Chondroitin sulfate plus Chloroquine
• Glucosamine,Chondroitin sulfate,Prednisolone,Chloroquine

Primary outcomes

• The primary outcome measures is defined as the change from baseline to final assessment of the study knee in the 3 core continuous variables pain and physical function, assessing using the WOMAC subscales, and patient global assessment (PGA) — Baseline
• The primary outcome measures is defined as the change from baseline to final assessment of the study knee in the 3 core continuous variables pain and physical function, assessing using the WOMAC subscales, and patient global assessment (PGA) — the outcome is assessed at 6 weeks after baseline visit
• The primary outcome measures is defined as the change from baseline to final assessment of the study knee in the 3 core continuous variables pain and physical function, assessing using the WOMAC subscales, and patient global assessment (PGA) — the outcome is assessed at 12 weeks after baseline visit

Countries

Iran