NCT00803725 is a NA clinical trial of Mepivacaine without fentanyl in Knee Arthroscopy, sponsored by University Health Network, Toronto.

Who is sponsoring NCT00803725?

NCT00803725 is sponsored by University Health Network, Toronto.

What drugs are being tested in NCT00803725?

Interventions in NCT00803725: Mepivacaine without fentanyl, Mepivacaine with Fentanyl.

What condition does NCT00803725 study?

NCT00803725 studies Knee Arthroscopy.

Is NCT00803725 still recruiting?

NCT00803725 is currently completed. Last updated 22 January 2010.

Last reviewed 2010-01-22 · How we verify

NCT00803725

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Spinal Mepivicaine With Fentanyl for Outpatient Knee Arthroscopy Surgery

Completed NA Last updated 22 January 2010

What this trial tests

NA trial testing Mepivacaine without fentanyl in Knee Arthroscopy in 34 participants. Completed in 1 May 2009.

Timeline

1 August 2008

Primary endpoint
1 May 2009

1 May 2009

Quick facts

Lead sponsor	University Health Network, Toronto
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	34
Start date	1 August 2008
Primary completion	1 May 2009
Estimated completion	1 May 2009
Sites	1 location across Canada

Drugs / interventions tested

Mepivacaine without fentanyl — full drug profile →
Mepivacaine with Fentanyl — full drug profile →

Conditions studied

Knee Arthroscopy — all drugs for Knee Arthroscopy →

Sponsor

University Health Network, Toronto

Who can join

Adults 18 to 80, any sex, with Knee Arthroscopy. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Time to complete motor block regression (0) as measured by modified Bromage scale.
Time frame: Every 2 minutes from administration of the spinal until complete onset.

Sponsor's own description

The purpose of this study is to determine if the addition of intrathecal fentanyl to low dose mepivacaine spinal anesthesia provides adequate surgical anesthesia with shorter duration of motor blockade. It is hypothesized that lower doses of spinal mepivacaine when combined with fentanyl will result in adequate surgical block for knee arthroscopy surgery with faster recovery and discharge compared to mepivacaine alone.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Spinal mepivacaine with fentanyl for outpatient knee arthroscopy surgery: a randomized controlled trial.
O'Donnell D, Manickam B, Perlas A, Karkhanis R, et al · · 2010 · cited 21× · PMID 19856040 · DOI 10.1007/s12630-009-9207-6

Verify or expand the search:

Other recruiting trials for Knee Arthroscopy

Currently open trials in the same condition.

NCT07423754 — Investigation of the Effects of Two Different Anaesthesia Methods Applied to Patients Scheduled for Arthroscopic Knee Su · NA · active not recruiting
NCT07276061 — Outpatient Total Knee Arthroscopy (TKA): Comparison of Postoperative Recovery Versus a Conventional Hospitalization · recruiting

Other University Health Network, Toronto trials

Trials by the same sponsor.

NCT06831032 — Elective Adaptive Radiation With SBRT for Improved DurabilitY of Response · NA · recruiting
NCT06634056 — Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients U · Phase 2 · not yet recruiting
NCT06836726 — Clinical Trial to Test Efficacy of Targeting Hypoxia Combined With ARSI After First-line ARSI Therapy for Castrate Resis · Phase 2 · not yet recruiting
NCT07515651 — Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas · Phase 2 · not yet recruiting
NCT07509450 — Fecal Microbiota Transplantation in Patients Undergoing Chimeric Antigen Receptor T-cell Therapy and Allogeneic Stem Cel · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00803725 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Health Network, Toronto
Last refreshed: 22 January 2010

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00803725.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing