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The Effects of Local Vaginal Estrogen in Postmenopausal Women With Pelvic Organ Prolapse: A Randomized Control Trial
The purpose of this study is to find out how long it takes the vagina to respond to hormonal vaginal cream in women with pelvic organ prolapse (bulge in the vagina). It also will address the appropriate amount to use prior to vaginal repair of pelvic organ prolapse.
Details
| Lead sponsor | TriHealth Inc. |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 54 |
| Start date | 2008-12 |
| Completion | 2011-05 |
Conditions
- Pelvic Organ Prolapse
- Vaginal Atrophy
Interventions
- Vaginal conjugated estrogen cream 0.5gm
- Vaginal conjugated estrogen cream 1.0gm
Primary outcomes
- Vaginal tissue samples obtained at the time of vaginal repair of pelvic organ prolapse will be analyzed for epithelial and subepithelial thickness, vascularity and inflammatory cells using standard H&E stains. — baseline and 2-12 weeks after treatment (at time of surgery)
Countries
United States