The Effect of GHRH Therapy on Myocardial Structure and Function in Congestive Heart Failure

NCT00791843 Phase 2 COMPLETED Results posted

PP1- The purpose of this study is to determine whether giving more of the hormone produced by everyone called growth hormone releasing hormone (GHRH) can improve heart function in individuals with congestive heart failure. You must be 50 years old or older, have a diagnosis of congestive heart failure, and have a high likelihood of having lower than normal growth hormone effect. GHRH is approved by the US FDA for treatment in children with growth hormone deficiency because GHRH stimulates Growth Hormone (GH). Its use for treatment of congestive heart failure in adults is investigational. Growth hormone releasing hormone is a hormone produced in the brain. We will be using synthetic hormone made in the laboratory. It is identical to the hormone in the brain. Many older people, due to aging have low levels of growth hormone. The aim of this study is to find out whether restoring growth hormone levels to the levels found in younger individuals and then maintaining those levels for 12 weeks will help strengthen heard muscles in older persons with congestive heart failure.

Details

Lead sponsor	University of Pennsylvania
Phase	Phase 2
Status	COMPLETED
Enrolment	3
Start date	2004-03
Completion	2011-08

Conditions

• Congestive Heart Failure

Interventions

• Growth hormone releasing hormone/ placebo

Primary outcomes

• PP1- Serum IGF-1 Levels, DXA, Resting Metabolic Rate, Total Body Water, 3-D Echo, Cardiac MRI, Dobutamine Stress Echocardiogram, Ergometry, General Health Assessment, Physical Exam — baseline, 12, 18, and 30 weeks

Countries

United States