Who is sponsoring ASTRIDE?

ASTRIDE is sponsored by Novartis.

What condition does ASTRIDE study?

ASTRIDE studies Hypertension, Diabetes Mellitus.

What drugs are being tested in ASTRIDE?

Interventions: Amlodipine, Hydrochlorothiazide (HCTZ), Aliskiren.

What is the status of ASTRIDE?

ASTRIDE is currently COMPLETED.

Last reviewed 2016-09-20 · How we verify

An 8-week Study to Evaluate the Efficacy and Safety of Aliskiren HCTZ (300/25 mg) Compared to Amlodipine (10 mg) in Patients With Stage 2 Systolic Hypertension and Diabetes Mellitus (ASTRIDE)

NCT00787605 Phase 4 COMPLETED Results posted

The purpose of the study is to evaluate the blood pressure lowering effect and safety of aliskiren in combination with Hydrochlorothiazide (HCTZ) given to diabetic patients with stage 2 systolic hypertension (mean sitting systolic blood pressure (msSBP) ≥ 160 mm Hg and \< 200 mm Hg).

Details

Lead sponsor	Novartis
Phase	Phase 4
Status	COMPLETED
Enrolment	860
Start date	2008-11
Completion	2010-01

Conditions

Hypertension
Diabetes Mellitus

Interventions

Amlodipine
Hydrochlorothiazide (HCTZ)
Aliskiren

Primary outcomes

Change From Baseline in Mean Sitting Systolic Blood Pressure (msSBP) — Baseline and Week 8

Countries

United States