Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation

NCT00763997 NA COMPLETED

Dipyrone is suggested to inhibit the platelet aggregation comparable to th effect of traditional analgetic substances like Ibuprofen. To verify this hypothesis the investigators conducted the study in comparing patients undergoing traumatologic, visceral or plastic surgical procedures. The investigators randomized them to four groups receiving common analgetic doses of either dipyrone, acetaminophen (paracetamol) or valdecoxib/parecoxib. The investigators took blood samples before initiation of the study drug, 1h, 4hs and 24hs after first intake. The investigators compared the aggregation via aggregometry of platelet rich plasma.

Details

Lead sponsor	Ruhr University of Bochum
Phase	NA
Status	COMPLETED
Enrolment	80
Start date	2004-02
Completion	2004-12

Conditions

• Platelet Aggregation

Interventions

• dipyrone
• Ibuprofen
• Acetaminophen
• Acetaminophen
• Parecoxib/Valdecoxib
• Blood samples

Primary outcomes

• Percentage of aggregation in platelet rich plasma fter 24 hours of treatment with analgetic doses — 24 hours

Countries

Germany