Who is sponsoring NCT00760734?

NCT00760734 is sponsored by Paul G. Harch, M.D..

What drugs are being tested in NCT00760734?

Interventions in NCT00760734: Low pressure hyperbaric oxygen therapy, Low pressure hyperbaric oxygen therapy.

What condition does NCT00760734 study?

NCT00760734 studies TBI (Traumatic Brain Injury), Post Concussion Syndrome, Post Traumatic Stress Disorder, Chronic Post Traumatic Stress Disorder.

Is NCT00760734 still recruiting?

NCT00760734 is currently completed. Last updated 16 April 2017.

Last reviewed 2017-04-16 · How we verify

NCT00760734

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

HBOT in Chronic Traumatic Brain Injury/Post Concussion Syndrome and TBI/PTSD Pilot Trial

Completed Phase 1 Last updated 16 April 2017

What this trial tests

Phase 1 trial testing Low pressure hyperbaric oxygen therapy in TBI (Traumatic Brain Injury) in 30 participants. Completed in 1 June 2011.

Timeline

1 September 2008

Primary endpoint
1 September 2010

1 June 2011

Quick facts

Lead sponsor	Paul G. Harch, M.D.
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	30
Start date	1 September 2008
Primary completion	1 September 2010
Estimated completion	1 June 2011
Sites	1 location across United States

Drugs / interventions tested

Low pressure hyperbaric oxygen therapy — full drug profile →
Low pressure hyperbaric oxygen therapy — full drug profile →

Conditions studied

TBI (Traumatic Brain Injury) — all drugs for TBI (Traumatic Brain Injury) →
Post Concussion Syndrome — all drugs for Post Concussion Syndrome →
Post Traumatic Stress Disorder — all drugs for Post Traumatic Stress Disorder →
Chronic Post Traumatic Stress Disorder — all drugs for Chronic Post Traumatic Stress Disorder →

Sponsor

Paul G. Harch, M.D. — full company profile →

Who can join

Adults 18 to 65, any sex, with TBI (Traumatic Brain Injury) or Post Concussion Syndrome. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Psychometric testing
Time frame: 30 days

Sponsor's own description

This is a pilot trial to see if one or two 40 treatment courses of low pressure hyperbaric oxygen therapy can improve cognition and brain imaging in subjects with either chronic mild-moderate traumatic brain injury (TBI), also known as post-concussion syndrome (PCS) or chronic PCS with post-traumatic stress disorder (PTSD) secondary to blast injury.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder.
Harch PG, Andrews SR, Fogarty EF, Lucarini J, et al · · 2017 · cited 30× · PMID 29152209 · DOI 10.4103/2045-9912.215745
Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury.
Eve DJ, Steele MR, Sanberg PR, Borlongan CV. · · 2016 · cited 21× · PMID 27799776 · DOI 10.2147/ndt.s110126

Verify or expand the search:

Other recruiting trials for TBI (Traumatic Brain Injury)

Currently open trials in the same condition.

NCT07103200 — Evaluation of Decision-Making Fatigue After Traumatic Brain Injury · NA · recruiting
NCT05205174 — Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury · NA · recruiting
NCT06867666 — Behavioral Treatment of Insomnia in Active-Duty Service Members With Traumatic Brain Injury · NA · recruiting
NCT05327829 — Stimulating After Recovery From Traumatic Brain Injury · EARLY_PHASE1 · recruiting
NCT06467708 — Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00760734 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Paul G. Harch, M.D.
Last refreshed: 16 April 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00760734.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing