"Effects of Oral Citrulline on Protein Metabolism in Healthy Humans: a Prospective, Randomized, Double-blind , Cross-over Study"

NCT00756080 Phase 1 COMPLETED

The specific aim of this study is to determine whether oral citrulline administration enhances whole body protein synthesis in healthy humans in the postabsorptive state. Protein metabolism will be assessed using an intravenous infusion of stable isotope labeled leucine. The investigators hypothesize that citrulline supplementation will decrease leucine oxidation without altering proteolysis, and consequently stimulate protein synthesis .

Details

Lead sponsor	Nantes University Hospital
Phase	Phase 1
Status	COMPLETED
Enrolment	12
Start date	2008-09
Completion	2009-01

Conditions

• Healthy Subjects

Interventions

• citrulline
• placebo

Primary outcomes

• To determine whether oral citrulline administration enhances whole body protein synthesis in healthy humans in the psotabsorptive state, as measured using an intravenous infusion of stable isotope labeled leucine

Countries

France