NCT00748943 is a Phase 1 clinical trial of Chlorine Dioxide in Halitosis, sponsored by Tokyo Medical and Dental University.

Who is sponsoring NCT00748943?

NCT00748943 is sponsored by Tokyo Medical and Dental University.

What drugs are being tested in NCT00748943?

Interventions in NCT00748943: Chlorine Dioxide.

Is NCT00748943 still recruiting?

NCT00748943 is currently completed. Last updated 11 September 2008.

Last reviewed 2008-09-11 · How we verify

NCT00748943

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Clinical Effects of a Mouthwash Containing Chlorine Dioxide on Oral Malodor and Salivary Periodontal and Malodorous Bacteria Using for 7days

Completed Phase 1 Last updated 11 September 2008

What this trial tests

Phase 1 trial testing Chlorine Dioxide in Halitosis in 15 participants. Completed in 1 June 2007.

Timeline

1 March 2007

Primary endpoint
1 May 2007

1 June 2007

Quick facts

Lead sponsor	Tokyo Medical and Dental University
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	prevention
Enrollment	15
Start date	1 March 2007
Primary completion	1 May 2007
Estimated completion	1 June 2007

Drugs / interventions tested

Chlorine Dioxide — full drug profile →

Conditions studied

Halitosis — all drugs for Halitosis →

Sponsor

Tokyo Medical and Dental University

Who can join

Adults 19 to 38, male only, with Halitosis. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Oral malodor
Time frame: 7 days

Sponsor's own description

Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2). However, no clinical studies have investigated its microbiological efficacies on periodontal and malodorous bacteria. The aim of this study was to assess the inhibitory effects of a mouthwash containing ClO2 on morning oral malodor and on salivary periodontal and malodorous bacteria using for 7 days.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial.
Shinada K, Ueno M, Konishi C, Takehara S, et al · · 2010 · cited 45× · PMID 20152022 · DOI 10.1186/1745-6215-11-14
Interventions for managing halitosis.
Kumbargere Nagraj S, Eachempati P, Uma E, Singh VP, et al · · 2019 · cited 29× · PMID 31825092 · DOI 10.1002/14651858.cd012213.pub2

Verify or expand the search:

Other recruiting trials for Halitosis

Currently open trials in the same condition.

NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
NCT06900881 — Role of Kefir Mouth Wash in Oral Health Status Amelioration · Phase 2, PHASE3 · recruiting
NCT06882564 — Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyrymonas Gingivalis. · Phase 3 · recruiting
NCT06583720 — Comparative Study Between Photodynamic Therapy with LED Associated with Probiotics in the Treatment of Halitosis · Phase 1 · recruiting
NCT06483646 — Evaluation of the Stability of Sulfur Volatile Compounds From Exhaled Air for Halitosis Diagnosis · NA · recruiting

Other Tokyo Medical and Dental University trials

Trials by the same sponsor.

NCT06135714 — Metastasis-directed Therapy for Oligometastases of Breast Cancer · Phase 3 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00748943 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Tokyo Medical and Dental University
Last refreshed: 11 September 2008

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00748943.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing