Last reviewed · How we verify
Loss of Effect of Aspirin on Platelet Aggregation During Chronic Administration
Aspirin has shown to be beneficial to some patients with certain diseases such as coronary artery disease or stroke. We are investigating how aspirin works on regulating platelets and thromboxane over time at different doses. We hope to find the best dose of aspirin and/or other medications to help people who are at risk for heart attack or stroke.
Details
| Lead sponsor | Vanderbilt University |
|---|---|
| Phase | Phase 4 |
| Status | TERMINATED |
| Enrolment | 51 |
| Start date | 2004-06 |
| Completion | 2011-02 |
Conditions
- Platelet Aggregation
Interventions
- aspirin
- aspirin
- placebo
Primary outcomes
- Comparison of platelet aggregation, serum thromboxane B2 (TxB2) levels, urinary thromboxane metabolite (Tx-M) levels, and urinary prostacyclin metabolite (PGI-M) levels over time and across dose ranges. — 11 weeks
Countries
United States