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NCT00738348: KMS
Effect of Perioperative Sivelstat Administration for Liver Resection
NA trial testing sivelstat in Liver Diseases in 50 participants. Completed in 1 July 2008.
1 May 2008
Quick facts
| Lead sponsor | Kochi University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | single group |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 50 |
| Start date | 1 April 2007 |
| Primary completion | 1 May 2008 |
| Estimated completion | 1 July 2008 |
| Sites | 1 location across Japan |
Drugs / interventions tested
Conditions studied
- Liver Diseases — all drugs for Liver Diseases →
Sponsor
Kochi University
Who can join
Eligibility, any sex, with Liver Diseases. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
The incidence of liver damage due to reperfusion injury by Pringle maneuver was measured by several cytokines, including IL-8, IL-6, and HMGB-1.
Time frame: during hospitalization
Sponsor's own description
It is reported that sivelstat improved and preserved the postoperative renal function in the orthopedic management. Moreover because sivelstat reduced the migration of neutrophil, it improved acute lung injury. During liver resection, Pringle maneuver, clamping the hepatoduodenal ligament, was performed. Pringle maneuver causes reperfusion injury of the liver. We have a hypothesis that sivelstat prevent the warm shock of reperfusion injury of the liver by Pringle maneuver.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT00738348
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Other Kochi University trials
Trials by the same sponsor.
- NCT06555510 — Preoperative Edema is a Significant Risk Factor for Post-hepatectomy Complications · completed
- NCT05268692 — Neoadjuvant Chemotherapy for Pancreatic Cancer Followed by GS and GnP · Phase 2, PHASE3 · recruiting
- NCT05257434 — Postoperative Outcomes in Patients With Hepato-biliary-pancreatic Cancer According to inBody Test · recruiting
- NCT05257226 — Both Short- and Long-term Outcome Differences According to Patient Frailty · recruiting
- NCT06809374 — Investigation of the Optimal Duration of Neoadjuvant Therapy for Resectable Pancreatic Cancer · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00738348 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kochi University
- Last refreshed: 6 June 2012
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00738348.
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