NCT00734968 is a Phase 4 clinical trial of Nitrofurantoin in Stress Incontinence, sponsored by University of Missouri-Columbia.

Who is sponsoring NCT00734968?

NCT00734968 is sponsored by University of Missouri-Columbia.

What drugs are being tested in NCT00734968?

Interventions in NCT00734968: Nitrofurantoin, Placebo.

What condition does NCT00734968 study?

NCT00734968 studies Stress Incontinence.

Is NCT00734968 still recruiting?

NCT00734968 is currently completed. Last updated 17 August 2016.

Are results published for NCT00734968?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2016-08-17 · How we verify

NCT00734968

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Does Prophylaxis With Macrobid Reduce the Incidence of Urinary Tract Infection in Patients Who Receive a Sub-Urethral Sling for the Treatment of Stress Urinary Incontinence: Randomized, Double Blinded Placebo Controlled Clinical Trial

Completed Phase 4 Results posted Last updated 17 August 2016

What this trial tests

Phase 4 trial testing Nitrofurantoin in Stress Incontinence in 161 participants. Completed in 1 May 2010.

Timeline

1 May 2008

Primary endpoint
1 May 2010

1 May 2010

Quick facts

Lead sponsor	University of Missouri-Columbia
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	161
Start date	1 May 2008
Primary completion	1 May 2010
Estimated completion	1 May 2010
Sites	1 location across United States

Drugs / interventions tested

Nitrofurantoin (NITROFURANTOIN) — full drug profile →
Placebo

Conditions studied

Stress Incontinence — all drugs for Stress Incontinence →

Sponsor

University of Missouri-Columbia

Who can join

18 and older, female only, with Stress Incontinence. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Incidence of Post-operative UTI Following the Placement of Sub-urethral Sling for the Treatment of Stress Urinary Incontinence
Time frame: 6 weeks
The overall rate of UTI following the placement of sub-urethral sling for the treatment of stress urinary incontinence in our study was 24.8% (n = 37)
Incidence of Post-operative UTI in Placebo Group
Time frame: 6 weeks
The incidence of UTI in the placebo group was 32%.
Incidence of Post-operative UTI in Treatment Group
Time frame: 6 weeks
The incidence of UTI in the nitrofurantoin group was 17.6%.

Sponsor's own description

This project will determine whether post-operative prophylaxis with macrobid will decrease the incidence of postoperative urinary tract infection in women receiving sub-urethral slings for the treatment of urinary incontinence.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Nitrofurantoin

Trials testing the same drug.

NCT07202832 — Urine Alkalinization for UTI in Women: RCT · NA · not yet recruiting
NCT07186465 — Microbiome-Modulating Prophylaxis RCT: Antibiotic vs Gynoflor in Postmenopausal Women With Recurrent Cystitis · Phase 4 · recruiting
NCT06332781 — Intravesical Gentamicin to Prevent Recurrent UTI · Phase 4 · completed
NCT05274672 — Role of Prophylactic Postoperative Antibiotics in HoLEP · Phase 4 · withdrawn
NCT05630833 — A Study to Investigate the Efficacy and Safety With Gepotidacin in Japanese Female Participants With Uncomplicated Urina · Phase 3 · completed

Other recruiting trials for Stress Incontinence

Currently open trials in the same condition.

NCT06352879 — Prevalence, Types and Risk Factors of Urinary Incontinence Among Women in Baghdad, Iraq. · recruiting

Other University of Missouri-Columbia trials

Trials by the same sponsor.

NCT07478172 — Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease · NA · recruiting
NCT07385105 — Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI) · NA · not yet recruiting
NCT07067502 — Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations · NA · not yet recruiting
NCT07424079 — Metacognitive Strategy Training Intervention for Transition-Age Youth With Cerebral Palsy · NA · not yet recruiting
NCT07216196 — The Feasibility of a Remote Problem-Solving Intervention for Autistic Adolescents or Young Adults and a Caregiver · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00734968 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Missouri-Columbia
Last refreshed: 17 August 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00734968.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing