Vasopressin, Epinephrine, and Corticosteroids for Inhospital Cardiac Arrest: A Multicenter Randomized Controlled Trial (VSE-2)

NCT00729794 Phase 3 COMPLETED

The simultaneous activation of adrenergic and vasopressin receptors, in conjunction with a potential steroid-mediated enhancement of the vascular reactivity to epinephrine may have beneficial effects in patients with cardiac arrest. This hypothesis is supported by the single-center results of NCT 00411879. The investigators intend to either refute or provide definitive evidence supporting this hypothesis (and its generalizability) by conducting the present multicenter, randomized, controlled clinical trial of in hospital cardiac arrest.

Details

Lead sponsor	University of Athens
Phase	Phase 3
Status	COMPLETED
Enrolment	300
Start date	2008-09
Completion	2010-11

Conditions

• Cardiac Arrest

Interventions

• Vasopressin, Epinephrine, Methylprednisolone, Hydrocortisone
• Standard CPR Protocol with Epinephrine and two Placebos

Primary outcomes

• Return of Spontaneous Circulation for at least 15 min and Survival to Hospital Discharge with or without neurological recovery — 60 days

Countries

Greece