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A Pilot Study Comparing Inflammatory Biomarkers in Blood and CSF in Patients With Alzheimer's Disease and Age-Matched Controls
The purpose of this study is to examine the cerebrospinal fluid (CSF) of patients with Alzheimer's disease for biomarkers of inflammation and their response to the antibiotics doxycycline and rifampin. The results of this preliminary analysis will be used in defining the direction of further research.
Details
| Lead sponsor | McMaster University |
|---|---|
| Phase | Phase 3 |
| Status | UNKNOWN |
| Enrolment | 21 |
| Start date | 2008-05 |
| Completion | 2009-10 |
Conditions
- Alzheimer's Disease
Interventions
- doxycycline
- rifampin
- placebo
Primary outcomes
- IL-1beta — baseline and 12 months
- TNF-alpha — baseline and 12 months
- MCP-1 — baseline and 12 months
- IL-4 — baseline and 12 month
- IL-10 — baseline and 12 months
Countries
Canada