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The Effects of Latanoprost, Bimatoprost and Travoprost on Periocular Skin Pigmentation
The purpose of this study is to study changes in skin color that may be caused by using one of the three eye medicines: Xalatan, Travatan or Lumigan.
Details
| Lead sponsor | Summa Health System |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 89 |
| Start date | 2008-03 |
| Completion | 2011-04 |
Conditions
- Glaucoma
- Application Site Pigmentation Changes
Interventions
- latanoprost
- bimatoprost
- travoprost
Primary outcomes
- The Extent of Latanoprost, Bimatoprost and Travoprost Induced Periocular Skin Hyperpigmentation Over a One Year Time Course in Newly Diagnosed Primary Open Angle and Ocular Hypertension Patients. — one year
Periocular skin color was measured with the Minolta Chroma Meter CR-400 and the L\*a\*b\* system, also known as Commission Internationale de l'Eclairage. This is a well-accepted unit of measurement in which L\* corresponds to brightness and a\* and b\* correspond to chromaticity. Measurements were taken at baseline and 1 year. Data from each time point and each location (upper and lower eyelids or cheeks/face) were averaged, and subtracted from the baseline value for that location. Six predetermined areas on and around the upper and lower eyelid and 2 areas of the face/cheek were measured.Upper and lower eyelid values were averaged and reported as single value for each location ie;-upper eyelids, lower eyelid and cheek/face. A decrease in luminance indicates increased pigmentation at the site of measurement.
Countries
United States