Effect of Montelukast on the Airway Remodeling in Asthma Patients: Physiological-radiological Correlation

NCT00699062 Phase 4 COMPLETED

The distal lung contributes to asthmatic airway remodeling which is observed from early onset of the disease. Cysteinyl leukotrienes (CysLT) play important role in the pathogenesis of airway remodeling and antileukotrienes work to exert a certain degree of anti-inflammatory effect. The cysteinyl leukotriene antagonist Montelukast has been in vivo shown to significantly inhibit ovalbumin induced airway smooth muscle hyperplasia and subepithelial fibrosis in sensitized mice. This study aims to evaluate if Montelukast could reverse airway remodeling in asthma patients by a non-invasive approach-HRCT.

Details

Lead sponsor	Chinese Academy of Medical Sciences
Phase	Phase 4
Status	COMPLETED
Enrolment	40
Start date	2010-01
Completion	2012-01

Conditions

• Asthma

Interventions

• singular
• placebo

Primary outcomes

• To evaluate distal airway function using high-resolution CT and lung function test — 6 months
  To demonstrate that the correlation between non-invisive chest HRCT and lung function test in patients moderate-to-severe asthma

Countries

China