Exploring the Effects of Diazepam and Lorazepam on the Neural Correlates of Perceptual Priming and Explicit Memory in Healthy Volunteers (ibid)

NCT00696033 NA COMPLETED

Aims : * exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI * comparing lorazepam effects to diazepam (0.3 mg/kg)effects * exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI Hypothesis : * both diazepam and lorazepam will impair explicit memory performance, but lorazepam only will impair perceptual priming * lorazepam and diazepam will modify the normal correlates of information encoding within explicit memory * lorazepam only will alter the neural correlates of perceptual priming

Details

Lead sponsor	University Hospital, Strasbourg, France
Phase	NA
Status	COMPLETED
Enrolment	22
Start date	2007-07
Completion	2008-12

Conditions

• Healthy Subjects

Interventions

• Diazepam
• Lorazepam
• placebo

Primary outcomes

• Exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI — After a single oral intake

Countries

France