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NCT00655772
A Randomized, Double Blind, Crossover, Placebo-Controlled Clinical Trial to Assess the Effects of a Mouthwash Containing Chlorine Dioxide on Oral Malodor
Phase 1 trial testing Chlorine Dioxide in Halitosis in 15 participants. Completed in 1 April 2007.
1 March 2007
Quick facts
| Lead sponsor | Tokyo Medical and Dental University |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 15 |
| Start date | 1 February 2007 |
| Primary completion | 1 March 2007 |
| Estimated completion | 1 April 2007 |
| Sites | 1 location across Japan |
Drugs / interventions tested
- Chlorine Dioxide — full drug profile →
Conditions studied
- Halitosis — all drugs for Halitosis →
Sponsor
Tokyo Medical and Dental University
Who can join
Adults 19 to 38, male only, with Halitosis. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
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Oral malodor was evaluated at before rinsing, right after rinsing and follows up every 30 minutes till 4 hours with organoleptic measurements.
Time frame: 4 hours
Sponsor's own description
A mouthwash containing chlorine dioxide would be effective to reduce oral malodor.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
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Interventions for managing halitosis.
Kumbargere Nagraj S, Eachempati P, Uma E, Singh VP, et al · · 2019 · cited 29× · PMID 31825092 · DOI 10.1002/14651858.cd012213.pub2 -
A randomized double blind crossover placebo-controlled clinical trial to assess the effects of a mouthwash containing chlorine dioxide on oral malodor.
Shinada K, Ueno M, Konishi C, Takehara S, et al · · 2008 · cited 22× · PMID 19068114 · DOI 10.1186/1745-6215-9-71
Verify or expand the search:
- PubMed search for NCT00655772
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Halitosis
Currently open trials in the same condition.
- NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
- NCT06900881 — Role of Kefir Mouth Wash in Oral Health Status Amelioration · Phase 2, PHASE3 · recruiting
- NCT06882564 — Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyrymonas Gingivalis. · Phase 3 · recruiting
- NCT06583720 — Comparative Study Between Photodynamic Therapy with LED Associated with Probiotics in the Treatment of Halitosis · Phase 1 · recruiting
- NCT06483646 — Evaluation of the Stability of Sulfur Volatile Compounds From Exhaled Air for Halitosis Diagnosis · NA · recruiting
Other Tokyo Medical and Dental University trials
Trials by the same sponsor.
- NCT06135714 — Metastasis-directed Therapy for Oligometastases of Breast Cancer · Phase 3 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00655772 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tokyo Medical and Dental University
- Last refreshed: 4 April 2008
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00655772.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing