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Carvedilol vs.Metoprolol: A Comparison of Effects on Endothelial Function and Oxidative Stress in Response to Acute Hyperglycemia in Patients With Type 2 Diabetes and Hypertension
The purpose of this study is to determine if there are differences, (benefits) between carvedilol and metoprolol in the treatment of HTN in patients with type 2 diabetes. Specifically we will be looking at differences in blood pressure and blood sugar control, endothelial function, inflammation, oxidative stress and coagulation. Subjects will be randomized to one of the two beta-blockers and followed for 5 months. Each subject will undergo 4 inpatient studies where an oral glucose tolerance test will be done, Inflammatory and oxidative stress markers will be measured. Endothelial function will be measured using brachial artery ultrasound and laser skin Doppler
Details
| Lead sponsor | University of New Mexico |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 22 |
| Start date | 2004-01 |
| Completion | 2008-07 |
Conditions
- Diabetes
Interventions
- carvedilol
- metoprolol
Primary outcomes
- Number of Participants Assessed for Change in Markers of Inflammation (PAI-1) Following Treatment Compared to Baseline — 5 months
Reporting the number of participants with a change in markers of inflammation (PAI-1) following treatment compared to baseline.
Countries
United States