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NCT00641784
A Randomized Trial of Oral Nifedipine Versus Intravenous Magnesium Sulfate in the Acute Management of Preterm Labor in Women With Singleton Gestations, Intact Fetal Membranes, and Positive Vaginal Fetal Fibronectin
Phase 3 trial testing Magnesium in Labor, Premature in 200 participants. Terminated before completion.
1 March 2012
Quick facts
| Lead sponsor | MemorialCare |
|---|---|
| Phase | Phase 3 |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 200 |
| Start date | 1 March 2008 |
| Primary completion | 1 March 2012 |
| Estimated completion | 1 March 2012 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Magnesium — full drug profile →
- Nifedlipine — full drug profile →
Conditions studied
- Labor, Premature — all drugs for Labor, Premature →
Sponsor
MemorialCare — full company profile →
Who can join
Adults 18 to 55, female only, with Labor, Premature. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
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In women with singleton gestations, to contemporarily assess the efficacy of oral nifedipine versus intravenous magnesium sulfate in the acute management of preterm labor in terms of defined early and late neonatal measures
Time frame: At delivery
Sponsor's own description
In women with singleton gestations, to contemporarily assess the efficacy of oral nifedipine versus intravenous magnesium sulfate in the acute management of preterm labor in terms of defined early and late neonatal measures
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Tocolytics for delaying preterm birth: a network meta-analysis (0924).
Wilson A, Hodgetts-Morton VA, Marson EJ, Markland AD, et al · · 2022 · cited 37× · PMID 35947046 · DOI 10.1002/14651858.cd014978.pub2
Verify or expand the search:
- PubMed search for NCT00641784
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Magnesium
Trials testing the same drug.
- NCT07502482 — The Effect of Magnesium on Post-spinal Headaches · not yet recruiting
- NCT07309640 — The Effects of Magnesium (Mg) Supplement and Alternate Maxillary Expansion and Constriction (Alt-RAMEC) in Patient With · NA · not yet recruiting
- NCT07082894 — Effect of Preoperative Oral Magnesium on Emergence Agitation · NA · completed
- NCT07521358 — Magnesium Supplementation With Fluoxetine for Cognitive Function in Depression · NA · completed
- NCT07079514 — Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients · Phase 1, PHASE2 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00641784 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by MemorialCare
- Last refreshed: 17 September 2009
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00641784.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing