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A Prospective, Randomized, Blind, Multicenter Trial Comparing Orally Administered Trimethoprim-sulfamethoxazole With Intravenously Administered Cefuroxime and Metronidazole as Prophylaxis of Infection Following Elective Colorectal Surgery
The current standard Swedish infection prophylaxis in colorectal surgery is intravenously administered cefuroxime and metronidazole. this combination is well studied. The disadvantages of the regimen is "collateral damage" resulting from treatment with a cephalosporine and that the combination also serves as the first line of treatment for abdominal surgical infections. Serval Swedish surgical departments have for some years used a combination of orally administered trimethoprim-sulfamethoxazole and metronidazole. The combination is economical and believed to be effective but hitherto the outcome have not been properly researched. The aim of this study is to compare the efficacy of these two regimens in the prevention of infection after elective colorectal surgery.
Details
| Lead sponsor | Halmstad County Hospital |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 1073 |
| Start date | 2007-09 |
| Completion | 2012-05 |
Conditions
- Infection Prophylaxis in Colo Rectal Surgery
Interventions
- trimethoprim-sulfamethoxazole + metronidazole
- cefuroxime and metronidazole
Primary outcomes
- Cutaneous-,subcutaneous and intraabdominal infections — 4 weeks
Countries
Sweden