Impact of Remifentanil Administration on Laryngeal Reflex Responses in Pediatric Patients With Upper Respiratory Anesthetized With Propofol

NCT00611195 Phase 4 COMPLETED

To describe respiratory and laryngeal responses to laryngeal stimulation during propofol anesthesia in children with upper airway infections. To determine whether the co-administration of remifentanil blunts these reflex responses. To test whether the co-administration of remifentanil results in a significant reduction of apnea with laryngospasm in these patients. Hypotheses: I: In children with a URI undergoing anesthesia with propofol, the incidence of apnea and laryngospasm after controlled stimulation is expected to occur 2.5 times more frequently than in children without URI (20 vs. 8%). II: The incidence of apnea and laryngospasm is diminished after administration of remifentanil.

Details

Lead sponsor	Thomas Erb
Phase	Phase 4
Status	COMPLETED
Enrolment	62
Start date	2008-01
Completion	2012-12

Conditions

• Upper Respiratory Infections

Interventions

• propofol, remifentanil

Primary outcomes

• Occurence of laryngospasm (defined as complete closure of the vocal or false cords with apnea lasting >10sec) after laryngeal stimulation — 5min

Countries

Switzerland