Last reviewed · How we verify
NCT00594503
Hyperbaric Oxygen Therapy and SPECT Brain Imaging in Traumatic Brain Injury
Phase 1 trial testing Hyperbaric oxygen therapy in Residual Neurological, Cognitive, Emotional, Behavioral Effects From Traumatic Brain Injury in 45 participants. Status unknown.
1 December 2017
Quick facts
| Lead sponsor | Paul G. Harch, M.D. |
|---|---|
| Phase | Phase 1 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 45 |
| Start date | 1 January 2007 |
| Primary completion | 1 December 2017 |
| Estimated completion | 1 December 2018 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Hyperbaric oxygen therapy — full drug profile →
Conditions studied
- Residual Neurological, Cognitive, Emotional, Behavioral Effects From Traumatic Brain Injury — all drugs for Residual Neurological, Cognitive, Emotional, Behavioral Effects From Traumatic Brain Injury →
Sponsor
Paul G. Harch, M.D. — full company profile →
Who can join
Eligibility, any sex, with Residual Neurological, Cognitive, Emotional, Behavioral Effects From Traumatic Brain Injury. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
SPECT brain imaging
Time frame: After completion of HBOT
Only for those subjects in which SPECT brain imaging was performed before hyperbaric oxygen therapy
Sponsor's own description
Hypothesis: That SPECT brain imaging tracks and is consistent with clinical improvements in patients receiving hyperbaric oxygen therapy (HBOT) for chronic traumatic brain injury.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Detrimental Roles of Hypoxia-Inducible Factor-1α in Severe Hypoxic Brain Diseases.
Choi YK. · · 2024 · cited 23× · PMID 38674050 · DOI 10.3390/ijms25084465 -
Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury.
Eve DJ, Steele MR, Sanberg PR, Borlongan CV. · · 2016 · cited 21× · PMID 27799776 · DOI 10.2147/ndt.s110126
Verify or expand the search:
- PubMed search for NCT00594503
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Hyperbaric oxygen therapy
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- NCT06954376 — Hyperbaric Oxygen Therapy as a Neuroprotective Intervention in Pediatric Acquired Brain Injury With Cognitive Disability · NA · completed
- NCT06954389 — Hyperbaric Oxygen Therapy as a Neuroprotective Modality in Pediatric Acquired Brain Injury With Motor Disability · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00594503 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Paul G. Harch, M.D.
- Last refreshed: 16 April 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00594503.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing