Who is sponsoring NCT00579644?

NCT00579644 is sponsored by University of Nebraska.

What drugs are being tested in NCT00579644?

Interventions in NCT00579644: Combination of Minocycline and MTX or MTX alone, methotrexate.

What condition does NCT00579644 study?

NCT00579644 studies Rheumatoid Arthritis.

Is NCT00579644 still recruiting?

NCT00579644 is currently completed. Last updated 6 October 2023.

Last reviewed 2023-10-06 · How we verify

NCT00579644

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate Alone

Completed Phase 3 Last updated 6 October 2023

What this trial tests

Phase 3 trial testing Combination of Minocycline and MTX or MTX alone in Rheumatoid Arthritis in 91 participants. Completed in 31 May 2006.

Timeline

28 March 2001

Primary endpoint
31 May 2006

31 May 2006

Quick facts

Lead sponsor	University of Nebraska
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	91
Start date	28 March 2001
Primary completion	31 May 2006
Estimated completion	31 May 2006
Sites	1 location across United States

Drugs / interventions tested

Combination of Minocycline and MTX or MTX alone — full drug profile →
methotrexate — full drug profile →

Conditions studied

Rheumatoid Arthritis — all drugs for Rheumatoid Arthritis →

Sponsor

University of Nebraska

Who can join

Adults 19 to 75, any sex, with Rheumatoid Arthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine if a combination of methotrexate and minocycline works better than methotrexate alone in early Rheumatoid Arthritis

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Immunotherapy of Autoimmune Diseases with Nonantibiotic Properties of Tetracyclines.
Park CS, Kim SH, Lee CK. · · 2020 · cited 25× · PMID 33425432 · DOI 10.4110/in.2020.20.e47
Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF.
Song YJ, Choi IA, Meylan F, Demoruelle MK, et al · · 2020 · cited 11× · PMID 32381123 · DOI 10.1186/s13075-020-02198-9

Verify or expand the search:

Other recruiting trials for Rheumatoid Arthritis

Currently open trials in the same condition.

NCT07433335 — A Study to Assess the Safety and Tolerability of SR-878 in Patients With Rheumatoid Arthritis · Phase 1 · recruiting
NCT07491016 — Efficacy and Safety of Telitacicept Combined With Baricitinib for Refractory Rheumatoid Arthritis · recruiting
NCT07171983 — A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis · Phase 1 · recruiting
NCT07246096 — Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Rel · EARLY_PHASE1 · recruiting
NCT07363590 — A Clinical Study of MK-1045 in People With Lupus or Rheumatoid Arthritis (MK-1045-004) · Phase 1 · recruiting

Other University of Nebraska trials

Trials by the same sponsor.

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NCT07506993 — Inflammation in Clear Aligners With and Without Attachments · not yet recruiting
NCT07207850 — Parents Helping Parents for Youth Vaping Cessation · NA · not yet recruiting
NCT07237269 — Abi/Pred + ADT vs ADT in PSMA-Positive, Conventionally Node-Negative Prostate Cancer · Phase 2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00579644 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Nebraska
Last refreshed: 6 October 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00579644.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing