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International Collaborative Treatment Protocol for Infants Under One Year With Acute Lymphoblastic or Biphenotypic Leukemia (Interfant06)
RATIONALE: Giving chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving cyclosporine, methotrexate, leucovorin, and antithymocyte globulin before and after transplant may stop this from happening. It is not yet known which treatment regimen is most effective in treating acute leukemia. PURPOSE: This randomized clinical trial is studying how well different therapies work in treating infants with newly diagnosed acute leukemia.
Details
| Lead sponsor | Dutch Childhood Oncology Group |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 445 |
| Start date | 2006-01 |
Conditions
- Leukemia
Interventions
- anti-thymocyte globulin
- asparaginase
- busulfan
- cyclophosphamide
- cyclosporine
- cytarabine
- daunorubicin hydrochloride
- etoposide
- leucovorin calcium
- melphalan
Primary outcomes
- Disease-free survival
Countries
United States, Austria, Belgium, Czechia, France, Germany, Italy, Netherlands, United Kingdom