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Randomized Trial of Effectiveness and Acceptability of Three Alternative Regimens for Malaria Seasonal Intermittent Preventive Treatment in Senegal
The purpose of this trial is to compare the acceptability, efficacy and safety of three alternative drug regimens for use for seasonal Intermittent Preventive Treatment to prevent malaria in children. Children aged 2 months to 5 years will be randomized to receive IPT with one of three regimens during the transmission season: sulfadoxine-pyrimethamine (SP) plus amodiaquine, show to be highly effective for IPT in a recent trial; SP plus piperaquine, used for malaria prophylaxis in China for many years; or Duocotexcin (a combination of piperaquine with an artemisinin).
Details
| Lead sponsor | London School of Hygiene and Tropical Medicine |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 1833 |
| Start date | 2007-09 |
| Completion | 2007-12 |
Conditions
- Malaria
Interventions
- sulfalene-pyrimethamine plus amodiaquine
- dihydroartemisinin plus piperaquine
- sulfadoxine pyrimethamine plus piperaquine
Primary outcomes
- Incidence of malaria — Four months
Countries
Senegal