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Influence Of Early Antioxidant Supplements On Clinical Evolution And Organ Function In Critically Ill Cardiac Surgery, Major Trauma And Subarachnoid Hemorrhage Patients (Etude-AOX)
Critically ill patients are generally exposed to an increased oxidative stress, which is proportional to the severity of their condition. Endogenous antioxidant (AOX) defenses are depleted particularly in those patients with intense inflammatory response. The hypothesis tested is that early I:V: administration of a combination of AOX micronutrient supplements (Se, Zn, Vit C, Vit E, Vit B1) would improve clinical outcome in selected critically ill patients, by reinforcing the endogenous AOX defenses and reducing organ failure.
Details
| Lead sponsor | Centre Hospitalier Universitaire Vaudois |
|---|---|
| Phase | Phase 3 |
| Status | TERMINATED |
| Enrolment | 200 |
| Start date | 2003-01 |
| Completion | 2005-12 |
Conditions
- Critically Ill Patients
- Cardiac Surgery
- Trauma
- Subarachnoid Hemorrhage
Interventions
- Selenium (Se), Zinc (Zn), Vitamin C, Vitamin B1, Vitamin E
- Placebo
Primary outcomes
- Organ function (SOFA) with special additional attention to renal function — 3 months
Countries
Switzerland