Who is sponsoring NCT00512759?

NCT00512759 is sponsored by University Hospital, Basel, Switzerland.

What drugs are being tested in NCT00512759?

Interventions in NCT00512759: Goal-directed preload and afterload decrement.

What condition does NCT00512759 study?

NCT00512759 studies Acute Heart Failure.

Is NCT00512759 still recruiting?

NCT00512759 is currently completed. Last updated 21 November 2019.

Last reviewed 2019-11-21 · How we verify

NCT00512759: GALACTIC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Goal-directed Afterload Reduction in Acute Congestive Cardiac Decompensation Study

Completed Phase 4 Last updated 21 November 2019

What this trial tests

Phase 4 trial testing Goal-directed preload and afterload decrement in Acute Heart Failure in 781 participants. Completed in 21 February 2019.

Timeline

10 December 2007

Primary endpoint
24 August 2018

21 February 2019

Quick facts

Lead sponsor	University Hospital, Basel, Switzerland
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	781
Start date	10 December 2007
Primary completion	24 August 2018
Estimated completion	21 February 2019
Sites	12 locations across Brazil, Germany, Switzerland, Bulgaria, Spain

Drugs / interventions tested

Goal-directed preload and afterload decrement — full drug profile →

Conditions studied

Acute Heart Failure — all drugs for Acute Heart Failure →

Sponsor

University Hospital, Basel, Switzerland

Who can join

18 and older, any sex, with Acute Heart Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine whether an early goal-directed decrement of preload and afterload with a target systolic blood pressure of 90-110 mmHg by aggressive vasodilatation in patients with acute HF in the non-ICU setting is safe, and leads to a better clinical and economical outcome

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure: The GALACTIC Randomized Clinical Trial.
Kozhuharov N, Goudev A, Flores D, Maeder MT, et al · · 2019 · cited 93× · PMID 31846016 · DOI 10.1001/jama.2019.18598
Quantifying Hemodynamic Cardiac Stress and Cardiomyocyte Injury in Normotensive and Hypertensive Acute Heart Failure.
Kozhuharov N, Michou E, Wussler D, Belkin M, et al · · 2024 · cited 3× · PMID 38791061 · DOI 10.3390/biomedicines12051099
Comprehensive vasodilatation in women with acute heart failure: Novel insights from the GALACTIC randomized controlled trial.
Wussler D, Belkin M, Maeder MT, Walter J, et al · · 2023 · cited 2× · PMID 37871997 · DOI 10.1002/ejhf.3065

Verify or expand the search:

Other recruiting trials for Acute Heart Failure

Currently open trials in the same condition.

NCT06587854 — a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure · recruiting
NCT07008365 — The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure · Phase 3 · recruiting
NCT06465498 — Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography · NA · recruiting
NCT06597331 — Cardiac Assessment and Takotsubo-stunning Among COPD-exacerbations In-Hospital · recruiting
NCT06166654 — Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload · Phase 4 · recruiting

Other University Hospital, Basel, Switzerland trials

Trials by the same sponsor.

NCT07444788 — Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants · Phase 1 · recruiting
NCT07494214 — Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants · Phase 1 · recruiting
NCT07419048 — Artificial Intelligence or Human Hand? Evaluating Inferior Vena Cava Imaging for Hydration Status · recruiting
NCT06978777 — Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity · NA · recruiting
NCT07273630 — Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00512759 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
Last refreshed: 21 November 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00512759.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing